Steering Toward Normative Wide-Dynamic-Range Neuron Activity in Nerve-Injured Rats With Closed-Loop Peripheral Nerve Stimulation.

Christine Beauchene,Claire A Zurn,Daniel Ehrens, Irina Duff,Wanru Duan,Michael Caterina,Yun Guan,Sridevi V Sarma

Neuromodulation : journal of the International Neuromodulation Society（2023）

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摘要

In this proof-of-concept study, we show how tractable, linear mathematical models of pain-related neurotransmission can be used to inform the development of closed-loop PNS. This new application of robust control to neurotechnology may also be expanded and applied across other neuromodulation applications.

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关键词

Chronic pain,model matching,peripheral nerve stimulation,robust control,wide-dynamic-range neuron

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