FGF21 negatively affects long-term female fertility in mice.

Beat Moeckli, Thuy-Vy Pham,Florence Slits, Samuel Latrille,Andrea Peloso,Vaihere Delaune,Graziano Oldani,Stéphanie Lacotte,Christian Toso

Heliyon（2022）

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摘要

A short-term treatment with FGF21 has a long-term effect on female fertility in mice. This represents a potential safety concern for FGF21 analogs currently in clinical development. Reproductive health outcomes should be included in upcoming clinical trials.

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关键词

FGF21,Fertility,High-fat diet,Non-alcoholic fatty liver disease

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