Early Increase of Circulating Transitional B Cells and Autoantibodies to Joint-Related Proteins in Patients With Metastatic Melanoma Developing Checkpoint Inhibitor-Induced Inflammatory Arthritis.

Mariele Gatto,Sara Bjursten,Charlotte A Jonsson,Monica Leu Agelii, Caroline Jonell,Sarah McGrath,Erik Lönnblom,Outi Sareila,Rikard Holmdahl,Anna Rudin,Max Levin,Inger Gjertsson

Arthritis & rheumatology (Hoboken, N.J.)（2022）

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摘要

Development of ICI-IA is accompanied by an increase in transitional B cells and by production of autoantibodies to joint-related proteins. Monitoring of B cell-driven abnormalities upon ICI treatment may help earlier recognition of ICI-IA.

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关键词

inhibitor–induced inflammatory arthritis,metastatic melanoma,checkpoint inhibitor–induced,autoantibodies

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