Increased relative biological effectiveness and periventricular radiosensitivity in proton therapy of glioma patients

Jan Eulitz,Esther G. C. Troost,Lauritz Klünder,Felix Raschke,Christian Hahn, Erik Schulz,Annekatrin Seidlitz,Justus Thiem, Caroline Karpowitz,Patricia Hahlbohm,Arne Grey,Kay Engellandt,Steffen Löck,Mechthild Krause,Armin Lühr

Radiotherapy and Oncology（2022）

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摘要

•Regional intra-cerebral variation in tissue response after proton therapy.•Increased relative biological effectiveness of proton therapy.•Spatial accumulation of radiation-induced brain injuries at cerebral ventricles and edge of clinical target volume.

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关键词

Proton therapy,Glioma brain tumours,Radiation-induced brain injury,Periventricular region,RBE,LET

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