Metabolic Changes Associated With Cardiomyocyte Dedifferentiation Enable Adult Mammalian Cardiac Regeneration.

Yuan-Yuan Cheng,Zachery Gregorich,Ray P Prajnamitra,David J Lundy, Ting-Yun Ma, Yu-Hsuan Huang,Yi-Chan Lee,Shu-Chian Ruan,Jen-Hao Lin,Po-Ju Lin,Chiung-Wen Kuo,Peilin Chen,Yu-Ting Yan,Rong Tian,Timothy J Kamp,Patrick C H Hsieh

Circulation（2022）

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摘要

Our data demonstrate the importance of HMGCS2-induced ketogenesis as a means to regulate metabolic response to CM injury, thus allowing cell dedifferentiation and proliferation as a regenerative response.

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关键词

HMGCS2,cell dedifferentiation,cell proliferation,cellular reprogramming,ketogenesis

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