Fabrication of pH responsive hydrogel blends of chondroitin sulfate/pluronic F-127 for the controlled release of ketorolac: its characterization and acute oral toxicity study.

Saba Naeem,Kashif Barkat,Maryam Shabbir,Ikrima Khalid,Irfan Anjum,Nadia Shamshad,Yasir Mehmood,Daulat Haleem Khan,Syed Faisal Badshah,Muhammad Ali Syed,Sana Afzal,Zainab Abdullah

Drug development and industrial pharmacy（2022）

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摘要

The prepared CS/Pl hydrogels demonstrated stimuli-controlled release with delivery of drug for prolonged period of time and thus can minimize dosing frequency, safe drug delivery, increased patient compliance and easiness.

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关键词

chondroitin sulfate,controlled release,free radical polymerization,ketorolac tromethamine,pH responsive

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