ANGPTL4 promotes nephrotic syndrome by downregulating podocyte expression of ACTN4 and podocin

Yue Li,Zichuan Xu, Hui Deng,Ming Liu,Xiaoqing Lin, Miao Zhang,Guanyu Li,Shuling Yue,Xia Gao

Biochemical and Biophysical Research Communications（2023）

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摘要

•ANGPTL4 is involved in podocyte injury in nephrotic mice.•Knockdown of angptl4 can reduce proteinuria in nephrotic mice.•The down-regulation of actin cytoskeleton regulatory signal by ANGPTL4 may be related to podocin.

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关键词

Angiopoietin-like protein 4,ACTN4,Podocin,TRPC6,Podocyte injury,Nephrotic syndrome

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