Loss of FoxOs in muscle increases strength and mitochondrial function during aging.

Christie M Penniman,Gourav Bhardwaj, Colette J Nowers, Chandler U Brown,Taylor L Junck,Cierra K Boyer,Jayashree Jena,Jordan D Fuqua,Vitor A Lira,Brian T O'Neill

Journal of cachexia, sarcopenia and muscle（2023）

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摘要

FoxO deletion increases muscle strength even during aging. Deletion of FoxOs maintains muscle strength in part by mild suppression of atrophic pathways, including inhibition of Gadd45a and Ube4a expression, without accumulation of autophagosomes in muscle. Deletion of FoxOs also improved mitochondrial function by maintenance of OXPHOS in both young and aged TKO.

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关键词

Aging,FoxO,Glucose tolerance,Insulin resistance,Mitochondrial function,Muscle hypertrophy

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