The impact of enteral feeding and therapeutic monitoring of rifampicin with dose-escalation in critically ill patients with tuberculosis.

Rubeshan Perumal,Kogieleum Naidoo,Anushka Naidoo, Marothi P Letsoalo,Aliasgar Esmail,Ivan Joubert,Paolo Denti,Lubbe Wiesner,Nesri Padayatchi,Gary Maartens,Keertan Dheda

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases（2022）

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摘要

We found low rifampicin concentrations in all patients receiving continuous enteral feeding. TDM-guided dose-escalation provided an effective strategy to achieve target drug exposure in these critically ill TB patients.

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关键词

Pharmacokinetics,critical illness,dose-adjustment,high-dose rifampicin,personalised medicine

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