Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia.

Hannah J Uckelmann,Elena L Haarer,Reina Takeda,Eric M Wong,Charlie Hatton,Christian Marinaccio,Florian Perner, Masooma Rajput,Noa J C Antonissen,Yanhe Wen,Lu Yang,Lorenzo Brunetti,Chun-Wei Chen,Scott A Armstrong

Cancer discovery（2023）

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摘要

We uncovered an important functional role of mutant NPM1 as a crucial direct driver of oncogenic gene expression in AML. NPM1c can bind to chromatin and cooperate with the MLL complex, providing the first functional insight into the mechanism of Menin-MLL inhibition in NPM1c leukemias. See related article by Wang et al., p. 724. This article is highlighted in the In This Issue feature, p. 517.

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acute myeloid leukemia,oncogenic transcription

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