Correlation of the TIGIT-PVR immune checkpoint axis with clinicopathological features in triple-negative breast cancer.

Florence Boissière-Michot,Marie-Christine Chateau,Simon Thézenas,Séverine Guiu,Angélique Bobrie,William Jacot

Frontiers in immunology（2022）

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摘要

These results indicated that in TNBC, TIGIT cells can easily interact with PVR to exert their inhibitory effects. Their wide expression in TNBC and their association with other immune checkpoint components suggest the therapeutic interest of the TIGIT-PVR axis.

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关键词

PVR (CD155),T-cell immunoglobulin and ITIM domain,TIGIT,human tumor,immunohistochemistry,triple negative breast cancer

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