Increased maternal non-oxidative energy metabolism mediates association between prenatal di-(2-ethylhexyl) phthalate (DEHP) exposure and offspring autism spectrum disorder symptoms in early life: A birth cohort study

Sarah Thomson,Katherine Drummond,Martin O'Hely,Christos Symeonides, Chitra Chandran,Toby Mansell,Richard Saffery,Peter Sly,Jochen Mueller,Peter Vuillermin,Anne-Louise Ponsonby

Environment International（2022）

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摘要

•Higher DEHP exposure linked to upregulated non-oxidative energy metabolism in pregnancy.•Upregulated prenatal maternal non-oxidative metabolism linked to more ASD symptoms.•Maternal metabolic shift partially mediates prenatal DEHP and ASD symptoms link.•Prenatal period is a sensitive window for phthalate effects.

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关键词

Endocrine disrupting chemicals,Metabolomics,Pyruvate metabolism,Warburg Effect,Autism spectrum disorder,Neurodevelopment

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