Synthesis, Biological Evaluation, and Docking Studies of Open-chain Carbohydrate Amides as Acetylcholinesterase Inhibitors.

R Gonçalves-Pereira,J A Figueiredo, S D Lucas,M I García-Moreno,C Ortiz Mellet,A P Rauter,M I Ismael

Medicinal chemistry (Shariqah (United Arab Emirates))（2022）

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摘要

Bonding is also significant through sugar interaction with the residues Tyr124 and Ser125-OH in both inhibitors. Flexibility of these open-chain structures seems to be quite relevant for the observed binding to acetylcholinesterase.

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关键词

Acetylcholinesterase inhibitors,Alzheimer’s disease,Docking studies,Open chain carbohydrate,Sugar amides,Synthesis

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