LncRNA SPRY4-IT1 facilitates cell proliferation and angiogenesis of glioma via the miR-101-3p/EZH2/VEGFA signaling axis.

Ji Wang,Yanming Chen,Qing Wang,Hui Xu,Qianqian Jiang, Man Wang,Shenggang Li,Ying Chen,Chunwang Wu,Pei Yu,Zongyu Xiao,Wenjin Chen,Qing Lan

Cancer medicine（2023）

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摘要

Our findings provide compelling evidence showing that SPRY4-IT1 upregulated EZH2 to induce VEGFA by sponging miR-101-3p, thereby achieving cell proliferation and angiogenesis in glioma. Therefore, targeting SPRY4-IT1/miR-101-3p/EZH2/VEGFA axis may improve the outcomes of patients with glioma.

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关键词

EZH2,SPRY4-IT1,VEGFA,angiogenesis,glioma,miR-101-3p,proliferation

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