THE INTERPLAY BETWEEN NON-CODING RNAS AND WNT/Beta-CATENIN SIGNALING PATHWAY IN URINARY TRACT CANCERS: FROM TUMORIGENESIS TO METASTASIS

Non-coding RNAs (ncRNAs) are emerging as important regulators in various pathological conditions including tumorigenesis, metastasis, and drug resistance in human cancers. Oncogenic or tumor suppressor ncRNAs exert prominent effects on cell proliferation, migration and invasion in cancer cells through modulating various signal-ing pathways including Wnt/13-catenin. Upregulation of the oncogenic Wnt/13-catenin pathway was reported to be implicated in multiple human cancers including breast, liver, colorectal, and urothelial cancers. Therefore, identi-fying interactions between ncRNAs and canonical Wnt signaling components may represent novel therapeutic targets for better treatment and management of cancer. In this review, we summarized the recent findings about miRNA/lncRNA-dependent mechanisms that regulate Wnt/13-catenin signaling involved in tumorigenesis and me-tastasis of urinary tract cancers.