TAT-LBD-Ngn2-improved cognitive functions after global cerebral ischemia by enhancing neurogenesis.

Bin Feng,Sansan Jia,Liya Li,Jiajia Wang,Fang Zhou,Xingchun Gou,Qiang Wang,Lize Xiong,Yi Zeng,Haixing Zhong

Brain and behavior（2023）

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摘要

Our findings revealed that TAT-LBD-Ngn2 could dramatically promote learning and memory in long term by facilitating neurogenesis in the hippocampus after global cerebral ischemia, indicating that TAT-LBD-Ngn2 may be an appealing candidate for treating poststroke NCD.

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关键词

global cerebral ischemia,neurogenesis,neurogenin2,post-stroke neurocognitive disorders,stroke

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