The influence of exocrine pancreatic function on the exposure and pharmacokinetics of ivacaftor in people with cystic fibrosis.

Renske van der Meer,Erik B Wilms, Margot N Eggermont, Helena M Paalvast, Richard C J M van Rossen,Harry G M Heijerman

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society（2022）

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摘要

The exocrine pancreatic function of pwCF does not significantly influence the absorption and exposure of ivacaftor. The use of pancreatic enzymes in PI pwCF does not change the absorption and exposure of ivacaftor. Therefore, the dosing advice as mentioned in the SmPC for ivacaftor can be maintained independent of the exocrine pancreatic function.

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关键词

Cystic fibrosis,Drug absorption,Exocrine pancreatic function,Ivacaftor,Pharmacokinetics

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