H3K27me3 Demethylases Maintain the Transcriptional and Epigenomic Landscape of the Intestinal Epithelium

Hannah M Kolev,Avital Swisa,Elisabetta Manduchi,Yemin Lan, Rachel R Stine,Giuseppe Testa,Klaus H Kaestner

Cellular and Molecular Gastroenterology and Hepatology（2023）

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摘要

Although KDM6A/B does not regulate intestinal cell differentiation, both enzymes are required to support the full transcriptomic and epigenomic landscape of the intestinal epithelium and the expression of key Paneth cell genes.

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关键词

ChIP-Seq,KDM6A,KDM6B,Lgr5+ ISCs,Paneth Cells,PRC2

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