Comparative study of extremely low-frequency electromagnetic field, radiation, and temozolomide administration in spheroid and monolayer forms of the glioblastoma cell line (T98).

Rasoul Yahyapour,Samideh Khoei,Zeinab Kordestani,Mohammad Hasan Larizadeh,Ali Jomehzadeh,Maryam Amirinejad,Meysam Ahmadi-Zeidabadi

Current radiopharmaceuticals（2022）

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摘要

The combinational use of TMZ, Rad and, EMF showed the highest antitumor activity by inducing apoptosis and autophagy signaling pathways and inhibiting cell cycle and drug resistance gene expression. Furthermore, EMF increased TMZ or radiation efficiency.

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关键词

Apoptosis,Autophagy,Cyclin-D1.,Glioblastoma,MGMT,Pulsed-electromagnetic field

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