Design and Optimization of Rivaroxaban-Cyclodextrin-Polymer Triple Complex Formulation with Improved Solubility.

Ji-Hyun Kang,Ji-Eun Lee,So-Jeong Jeong,Chun-Woong Park,Dong-Wook Kim,Kwon-Yeon Weon

Drug design, development and therapy（2022）

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摘要

The results imply that high-dose RIV can be administered regardless of the meal, reducing the risk of changing the drug effect due to the patient's administration mistake.

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关键词

design of experiment,drug-cyclodextrin-polymer triple complex,rivaroxaban,solubilization

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