Inferences for Current Chronic Graft-Versus-host-disease Free and Relapse Free Survival.
BMC Medical research methodology(2022)
摘要
This paper provides the methodologies of a new summary curve that measures the dynamic outcome following allogenic hematopoietic cell transplantation. This new summary curve computes the probabilities that a patient is alive in remission and free of severe-to-moderate chronic graft-versus-host disease (GVHD) over time. The probability is called Current chronic GVHD-free, Relapse-Free Survival (CGRFS). Based on a multistate model depicting the possible states that a patient may experience after transplant, CGRFS can be formulated as a linear combination of five survival functions. This method is known as the model-free approach. In this paper we provide the inferences of the model-free approach, including estimation of CGRFS, precision evaluation and comparison of CGRFS between two independent samples.
更多查看译文
关键词
Multistate,GRFS,Product integral,Kaplan-Meier estimator
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要