An Attractive and Efficient Procedure for Synthesis of Heterocyclic Structures: MNPs-Bis(2-Hydroxyethyl)-Guanidine-Ni Nanocomposite as a Novel and Green Nanomagnetic Catalyst for Multicomponent Reactions

Now, in this paper, we report the successful fabrication of MNPs-bis(2-hydroxyethyl)-guanidine-Ni nanocatalyst and study its catalytic behavior for the synthesis of pyrano[2,3-c]pyrazoles and highly functionalized piperidines. The Structure of the as-fabricated MNPs-guanidine-bis(ethanol)-Ni nanomaterial was fully characterized by advanced microscopic and spectroscopic methods, such as FT-IR, SEM, TEM, EDX, TGA, VSM, XRD and ICP-OES. With aryl aldehydes, ethyl acetoacetate, and aniline or malononitrile and hydrazine hydrate as the reactive species, the created MNPs-bis(2-hydroxyethyl)-guanidine-Ni catalytic agent acts as a promising candidate to deliver numerous pharmaceutically relevant highly functionalized piperidines and pyrano[2,3-c]pyrazoles scaffolds. The developed methodology comes with a host of advantageous features, such as gentle reaction conditions, a broad substrate range, great product yields, and a brief reaction time. Additionally, the Ni nanocatalyst could be easily recovered by a simple magnetic separation and recycled at least 8 times without deterioration in catalytic activity.