Continuous crystallization and its potential use in drug substance Manufacture: A review

Ayse Eren,Francesco Civati,Wenchuan Ma,Janaka C. Gamekkanda,Allan S. Myerson

Journal of Crystal Growth（2023）

引用 6|浏览11

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摘要

•Comprehensive review on continuous drug product manufacturing.•Discussion on mixed suspension mixed product removal (MSMPR) crystallizers.•Discussion on processes parameters’ effects on critical quality attributes.•Strategies in continuous processes to control the critical quality attributes.

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关键词

A2. Industrial crystallization,A1. Continuous crystallization,B3. MSMPRs,A1. Impurities,A1. Polymorphism,A1. Process design

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