Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling.

Felix Schreibing,Monica T Hannani,Hyojin Kim,James S Nagai,Fabio Ticconi,Eleanor Fewings,Tore Bleckwehl,Matthias Begemann, Natalia Torow,Christoph Kuppe,Ingo Kurth,Jennifer Kranz, Dario Frank, Teresa M Anslinger,Patrick Ziegler, Thomas Kraus,Jürgen Enczmann,Vera Balz, Frank Windhofer,Paul Balfanz,Christian Kurts,Gernot Marx, Nikolaus Marx,Michael Dreher,Rebekka K Schneider,Julio Saez-Rodriguez,Ivan Costa,Sikander Hayat,Rafael Kramann

Frontiers in immunology（2022）

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摘要

We propose a model in which differences in the surrounding inflammatory milieu lead to crucial differences in NK-like differentiation of CD8 effector T cells, ultimately resulting in the appearance of NK-like CD8 T cell populations of different functionality and pathogenicity. Our in-depth characterization of the CD8 T cell-mediated response to SARS-CoV-2 infection provides a basis for further investigation of the importance of NK-like CD8 T cells in COVID-19 severity.

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关键词

CD16,CD8+ T cells,FCGR3A,NK-like T cell,SARS-CoV-2,immunoprofiling,scRNA-seq,scTCR-seq

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