Amphetamines modulate fentanyl-depressed respiration in a bidirectional manner

Harrison J. Elder,Neil B. Varshneya,D. Matthew Walentiny,Patrick M. Beardsley

Drug and Alcohol Dependence（2022）

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摘要

•Fentanyl depresses respiration in mice that is refractory to naloxone reversal.•d- and methamphetamine decrease then increase basal respiration as dose increases.•Low-dose amphetamines further exacerbate fentanyl-depressed respiration.•High-dose amphetamines reverse fentanyl-depressed respiration.

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关键词

AMPH,FENT,METH,MVb,NLX,NSO,SAL,TVb,WBP

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