Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization.

Circulation（2023）

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摘要

These results not only establish decreased transcription by the variant as a cause of BrS, but also reveal a new general transcriptional mechanism of arrhythmogenesis of enhanced late sodium current caused by reduced PDGF receptor-mediated PI3K signaling.

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关键词

Brugada syndrome,arrhythmia,genetics,stem cells

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