Donepezil-loaded PLGA-b-PEG Nanoparticles Enhance the Learning and Memory Function of Beta-Amyloid Rat Model of Alzheimer's Disease.

Elif Çınar,Sevgi Uğur Mutluay,İpek Baysal,Merve Gültekinoğlu,Kezban Ulubayram,Samiye Yabanoğlu Çiftçi,Banu Cahide Tel,Gülberk Uçar

Noro psikiyatri arsivi（2022）

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摘要

Targeting with donepezil-loaded PLGA-b-PEG-NPs increases efficiency, helps to inhibit acetylcholinesterase activity more substantially, improves cognitive decline due to its longer duration of action and destabilizing effect on amyloid fibrils.

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关键词

Alzheimer’s disease,animal model,behavioral test,brain targeting,donepezil,nanoparticle

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