Elevated VCAM-1, MCP-1 and ADMA serum levels related to pulmonary fibrosis of interstitial lung disease associated with rheumatoid arthritis.
Frontiers in molecular biosciences(2022)
摘要
Early diagnosis of interstitial lung disease (ILD) associated with rheumatoid arthritis (RA) constitutes a challenge for the clinicians. Pulmonary vasculopathy is relevant in the development of interstitial lung disease. Accordingly, we aimed to explore the role of vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1) and asymmetric dimethylarginine (ADMA), key molecules in the vasculopathy, as potential biomarkers of pulmonary fibrosis in RA-ILD. We included 21 RA-ILD patients and two comparative groups: 25 RA-ILD patients and 21 idiopathic pulmonary fibrosis (IPF) patients. Serum levels of the molecules were determined by ELISA, and mRNA expression was quantified by qPCR. VCAM-1, MCP-1 and ADMA serum levels were increased in RA-ILD patients in relation to RA-ILD and IPF patients. Additionally, RA-ILD patients exhibited increased (gene encoding MCP-1) and decreased (gene related to ADMA synthesis) mRNA expression in relation to RA-ILD patients. A lower expression of , , and was observed in RA-ILD patients when compared with those with IPF. Furthermore, MCP-1 serum levels and mRNA expression were positively correlated with RA duration, and ADMA serum levels were positively associated with C-reactive protein in RA-ILD patients. Our study suggests that VCAM-1, MCP-1 and ADMA could be considered as useful biomarkers to identify ILD in RA patients, as well as to discriminate RA-ILD from IPF, contributing to the early diagnosis of RA-ILD.
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关键词
ADMA,MCP-1,VCAM-1,biomarkers,interstitial lung disease,pulmonary fibrosis,rheumatoid arthritis
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