From Weight Loss to Weight Gain: Utilizing the Full Spectrum of Weight Management for Behavioral Intervention.

Reducing the prevalence of overweight and obesity has been a primary focus in the management and prevention of chronic disease, including diabetes, cancer, and knee osteoarthritis (OA) 1 Chooi Y.C. Ding C. Magkos F. The epidemiology of obesity. Metabolism. 2019; 92: 6-10 Abstract Full Text Full Text PDF PubMed Scopus (1180) Google Scholar ,2 Jastreboff A.M. Kotz C.M. Kahan S. Kelly A.S. Heymsfield S.B. Obesity as a disease: the obesity society 2018 position statement. Obesity. 2019; 27: 7-9https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22378 Crossref PubMed Scopus (166) Google Scholar . Specific to knee OA, obesity can accelerate disease progression and contribute to disability. Consequently, a 5–10% weight loss combined with exercise is among the most prescribed and effective non-surgical treatments for knee OA, recommended as part of best practice by several international guidelines and resulting in important clinical and mechanistic outcomes, including reductions in pain and improvements in function and health-related quality of life.