Mitochondrial-targeted nanoparticles: Delivery and therapeutic agents in cancer

Chaithanya Ganji,Veda Muppala, Musaab Khan,Ganji Purnachandra Nagaraju,Batoul Farran

Drug Discovery Today（2023）

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摘要

Antitumor agents are delivered via nanoparticles (NPs) to the mitochondria. The drugs attack the mitochondria resulting in mitochondrial damage and the release of cytochrome C (Cyto-C). Cyto-C binds with Apaf1 and Caspase-9 to form an apoptosome. The apoptosome activates Caspase 3, which ultimately results in the death of cancer cells.

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关键词

cancer,mitochondria,nanoparticles,drug,therapy

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