Prenatal restraint stress downregulates the hypothalamic kisspeptidergic system transcripts genes, reduces the estrogen plasma levels, delayed the onset of puberty, and reduced the sexual behavior intensity in female rats

•Prenatal restraint stress (PRS)was administered from gestation day 17 to 20.•In female pups, PRS delays the female pups vaginal openings.•At adult age, PRS reduced the female sexual behavior and the estrogen levels.•PRS reduced the hypothalamic gene expression of kisspeptin protein (Kiss1) and Gpr54.•Effects were attributed. kisspeptidergic system downregulation of transcripts genes and estrogens levels.