Cytokine signaling converging on IL11 in ILD fibroblasts provokes aberrant epithelial differentiation signatures.

Miriam T Kastlmeier,Erika Gonzalez-Rodriguez,Phoebe Cabanis, Eva M Guenther, Ann-Christine König, Lianyong Han,Stefanie M Hauck,Fenja See, Sara Asgharpour,Christina Bukas,Gerald Burgstaller,Marie Piraud,Mareike Lehmann,Rudolf A Hatz,Jürgen Behr,Tobias Stoeger,Anne Hilgendorff,Carola Voss

biorxiv（2023）

引用 2|浏览7

暂无评分

摘要

We identified mediators likely contributing to the disease-perpetuating mesenchymal-to-epithelial crosstalk in ILD. In our alveolar organoid co-cultures, we were able to highlight the importance of fibroblast-initiated aberrant epithelial differentiation and confirmed IL11 as a key player in fibrotic-ILD pathogenesis by unbiased fibroblast secretome analysis.

查看译文

关键词

ild fibroblasts,il11,cytokine,epithelial

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要