Highly inert Cu(ii) complexes of C-aryl bifunctional cyclam-picolinates with remarkable Cu-64-labelling and biodistribution

Cyclam-picolinate chelators were functionalized via click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding Cu-64-radiocomplexes. The C-aryl functionalization strategy developed here preserves the chemical properties of the radiocomplexes whilst deeply enhancing their applications within nuclear medicine.