TIMP1 represses sorafenib-triggered ferroptosis in colorectal cancer cells by activating the PI3K/Akt signaling pathway.

Immunopharmacology and immunotoxicology（2023）

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摘要

The combination of sorafenib and GPX4 inhibitors such as RSL3 may be a promising therapy against CRC.

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关键词

PI3K/Akt pathway,TIMP1,colorectal cancer,ferroptosis,sorafenib

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