Persistence of envelopes in different CD4+ T-cell subsets in antiretroviral therapy-suppressed people with HIV.

Matthew J Gartner,Carolin Tumpach,Ashanti Dantanarayana,Jared Stern,Jennifer M Zerbato,J Judy Chang,Thomas A Angelovich,Jenny L Anderson,Jori Symons,Steve G Deeks,Jacqueline K Flynn,Sharon R Lewin,Melissa J Churchill,Paul R Gorry,Michael Roche

AIDS (London, England)（2023）

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摘要

Our data suggest the viral reservoir in PWH on ART was predominantly maintained over time through proliferation and potentially differentiation of infected cells. We found the humoral immune response to Envs within the latent reservoir was variable between PWH. Finally, we identified coreceptor usage can influence bNAb sensitivity and may need to be considered for future bNAb immunotherapy approaches.

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关键词

CCR5,CXCR4,HIV tropism,neutralization,reservoir,T-cell subsets

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