Association of serum CC16 levels with eosinophilic inflammation and respiratory dysfunction in severe asthma

Houman Goudarzi,Hirokazu Kimura,Hiroki Kimura,Hironi Makita,Michiko Takimoto-Sato,Yuki Abe,Akira Oguma,Munehiro Matsumoto,Nozomu Takei,Machiko Matsumoto-Sasaki,Kaoruko Shimizu,Masaru Suzuki,Noriharu Shijubo,Shau-Ku Huang,Nobuyuki Hizawa,Masaharu Nishimura,Satoshi Konno

Respiratory Medicine（2023）

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摘要

•CC16 was inversely associated with Th2 biomarkers and annual FEV1 decline in severe asthma patients.•CC16 may be valuable for predicting enhanced eosinophilic inflammation and rapid FEV1 decline in severe asthma.•Clinicians may assess current and future severe asthma outcomes according to baseline CC16 levels.

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关键词

CC16,Severe asthma,T-helper 2 biomarkers,Eosinophilic inflammation,Sputum eosinophils,Periostin,Respiratory function

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