Alcohol withdrawal produces changes in excitability, population discharge probability, and seizure threshold.
Alcoholism, clinical and experimental research(2023)
摘要
We demonstrate that the oPDT provides a sensitive measure of alcohol withdrawal-induced hyperexcitability. The ability to actively probe the progression of excitability without eliciting potentially confounding seizures promises to be a useful tool in the preclinical development of next-generation pharmacotherapies for AWS.
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关键词
alcohol withdrawal syndrome,electrophysiology,interictal spikes,optogenetics,seizure
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