Role of CD14+ monocyte-derived oxidised mitochondrial DNA in the inflammatory interferon type 1 signature in juvenile dermatomyositis.

Meredyth G Ll Wilkinson,Dale Moulding,Thomas C R McDonnell,Michael Orford,Chris Wincup, Joanna Y J Ting,Georg W Otto,Restuadi Restuadi,Daniel Kelberman,Charalampia Papadopoulou,Sergi Castellano,Simon Eaton,Claire T Deakin,Elizabeth C Rosser,Lucy R Wedderburn

Annals of the rheumatic diseases（2022）

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摘要

These results describe a novel pathway where altered mitochondrial biology in JDM CD14+ monocytes lead to oxmtDNA production and stimulates ISG expression. Targeting this pathway has therapeutical potential in JDM and other IFN type 1-driven autoimmune diseases.

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关键词

Autoimmune Diseases,Dermatomyositis,Inflammation

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