Mayo-PACC: A parsimonious preclinical Alzheimer's disease cognitive composite comprised of public-domain measures to facilitate clinical translation.

Nikki H Stricker,Erin L Twohy,Sabrina M Albertson,Aimee J Karstens,Walter K Kremers,Mary M Machulda,Julie A Fields,Clifford R Jack,David S Knopman,Michelle M Mielke,Ronald C Petersen

Alzheimer's & dementia : the journal of the Alzheimer's Association（2022）

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摘要

Mayo-PACC performs similarly to other composites and can be directly translated to the clinic.

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关键词

ADCS-PACC,PACC-R,aging,amyloid,biomarker,cognitive decline,cognitive outcome measure,embedded pragmatic clinical trials,global cognition,longitudinal,neuropsychology,practice effect,reliability,validity

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