EP347/#879 Detection of progression or regression of gynecologic cancers by circulating tumor DNA (CTDNA)
E-Posters(2022)
摘要
Objectives
The use of post-operative circulating tumor DNA (ctDNA) to detect cancer recurrence has been reported in various studies but the literature describing variable changes in ctDNA is limited. The objective of this study is to describe the utility of single and serial ctDNA values in detecting the progression or regression of gynecological cancers.Methods
This is a retrospective observational study including nineteen patients, aged >=18 years who had the ctDNA test completed at hematology/oncology clinic of William Beaumont – Royal Oak and Troy Hospitals, Michigan, USA.Results
Among the nineteen patients, fifteen had breast, three had ovarian, and one had endometrial cancer. The median age at diagnosis was 57 years, and 73.7% of patients had either stage III or IV disease. Our primary endpoint, the correlation of single ctDNA results with imaging showing either progression or residual disease, showed a sensitivity and specificity of 100% and 93.3%, respectively. Secondarily, serial ctDNA analysis in ten patients revealed both sensitivity and specificity of 100% for up-trending ctDNA to detect progression, down-trending to detect regression, and negative results to detect the absence of disease. The positive ctDNA results detected disease progression with a median lead-time of 36.5 days compared to imaging.Conclusions
Given the high sensitivity and specificity to detect disease progression and regression in gynecologic cancer by single and serial values in our study, we conclude that ctDNA can be a valid way to monitor for changes in disease status. Further clinical studies are required to prove the utility of ctDNA in detecting changes in disease status查看译文
关键词
tumor dna,gynecologic cancers,ctdna
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要