EP057/#158 Real-world patient profiles, treatment patterns, and outcomes among recurrent, persistent, and metastatic cervical cancer patients

Objectives

Real-world evidence among advanced cervical cancer (aCC) patients in the US is limited. This study evaluated patient characteristics, treatment patterns, and clinical outcomes among aCC patients under routine clinical care.

Methods

This retrospective study used the ConcertAI Oncology Dataset which draws from US oncology electronic medical records. Patients were ≥18 years, diagnosed with persistent, recurrent, or metastatic cervical cancer, and initiated systemic anti-cancer therapy between August 2014 and June 2021. Descriptive statistics were generated for patient characteristics and treatments. Kaplan-Meier product limit estimator was used to characterize time on treatment and real-world overall survival (rwOS).

Results

There were 325 patients with median age 51.5 years, 70.5% were White, and 47.7% were stage IVB at diagnosis. About 68.0% initiated bevacizumab in first line (1L) (Bev1L), 10.2% in 2L/3L (Bev2L/3L), and 21.8% did not receive bevacizumab (NoBev). The NoBev group was generally older and had more comorbidities, compared to patients on bevacizumab (table 1). Overall, the most common regimen received in 1L was bevacizumab-carboplatin-paclitaxel (38.5%), with median duration 3.51 months, followed by bevacizumab-cisplatin-paclitaxel (19.7%) with median duration 3.48 months, and carboplatin-paclitaxel (10.5%) with median duration 2.31 months. Median rwOS from 1L start was 16.5 months [95% CI:14.2, 19.9] overall, and generally higher in patients receiving bevacizumab (Bev1L 17.9 [14.5, 21.4] months, Bev2L/3L 16.0 [10.8, 43.6] months, and NoBev 10.5 [7.4, 32.7] months).

Conclusions

This study highlights burden of disease and unmet need for specific treatments in the real-world recurrent, persistent, and metastatic cervical cancer patients in the US.