EP277/#369 Abdominal tissue concentrations carboplatin and inflammatory protein in a hipec procedure – assessment in a novel experimental porcine model

Objectives

Peritoneal dissemination from ovarian cancers is associated with poor prognosis and rapid disease progression. Hyperthermic intraperitoneal chemotherapy (HIPEC) is an antineoplastic treatment, which has improved survival and recurrence-free survival, but little is known about the acquired chemotherapy concentrations in local tissues. The aim of this study was to assess concentrations of carboplatin and inflammatory protein markers during and after HIPEC treatment dynamically and simultaneously in various abdominal organ tissues by means of microdialysis in a novel porcine model.

Methods

8 pigs underwent imitation cytoreductive surgery followed by HIPEC (90 min) using a carboplatin dosage of 800 mg/m². Microdialysis catheters were placed for sampling of drug concentrations in various tissues: peritoneum, liver, bladder wall, mesentery, and in different depths of one mm and four mm in the hepatoduodenal ligament and rectum. During and after HIPEC, dialysates and blood samples were collected over eight hours.

Results

No significant differences in mean carboplatin AUC_0-last (range: 2657–5176 min x μg/mL), mean carboplatin C_max (range: 10.6–26.0 μg/mL) and mean carboplatin T_max (range: 105–206 min) were found between the compartments. In plasma there was a tendency towards lower measures. Inflammatory protein marker analysis is in progress, and there are no available results at the time of submission.

Conclusions

Equal carboplatin distribution in abdominal organ tissues, detectable concentrations for at least six hours after HIPEC completion, and a carboplatin penetration depth of minimum four mm were found. There are no available conclusions for the inflammatory protein marker results at the time of submission.