Chrome Extension
WeChat Mini Program
Use on ChatGLM
VIPCreated with Sketch.

    • ALTERATION IN SHEAR WAVE ELASTOGRAPHY IS ASSOCIATED WITH ACUTE KIDNEY INJURY: A PROSPECTIVE OBSERVATIONAL PILOT STUDY.

    Qiancheng Xu,Banghong Qiang,Youjun Pan,Juan Li,Lei Zha,Weihua Lu,Junli Wang,Jianguo Li

    Journal of Immunology（2023）SCI 2区SCI 3区

    Wuhan Univ | East China Normal Univ | Univ Liverpool | Wannan Med Coll

    Cited 1|Views34
    Abstract
    ABSTRACT:Background: Kidney stiffness could change during kidney disease. We hypothesize that acute kidney injury (AKI) would increase renal stiffness. Therefore, evaluating kidney Young's modulus (YM; a measure of tissue stiffness) using shear wave elastography (SWE) might help to diagnose AKI. Methods: This research was divided into two studies. Study A: Male C57BL/6 mice were used to observe kidney YM changes induced by sepsis-associated AKI, which was established by cecal ligation and puncture (CLP). Study B included 54 consecutive critically ill patients with or without AKI. Changes in renal YM were observed. Results: Study A: CLP mice showed a significantly higher kidney YM compared with the sham group. The YM gradually increased from CLP 0 hours to CLP 24 hours, and presented a fair relationship with the renal tubular injury score ( R2 = 0.71) and serum creatinine ( R2 = 0.73). Study B: YM was easily accessible, and the intraclass correlation coefficient ranged from 0.62 to 0.84. Kidney YM was higher in AKI patients and gradually increased from non-AKI to AKI III patients. Furthermore, the YM in the upper, middle, and lower poles of the renal cortex presented a fair relationship with kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin ( R2 ranging from 0.4 to 0.58), and the areas under the curve of the above five indicators for the diagnosis of AKI were 0.7, 0.73, 0.70, 0.74, and 0.79, respectively. Conclusion: SWE-derived estimates of renal stiffness are higher in AKI patients and sepsis-associated AKI mice. However, it has no advantage over NGAL and KIM-1. Trial Registration: Chinese Clinical Trial Registry No: ChiCTR2200061725. Retrospectively registered July 1, 2022, https://www.chictr.org.cn/showproj.aspx?proj=169359 .
    More
    Translated text
    Key words
    Acute kidney injury,shear wave elastography,ultrasonography,kidney stiffness,Young's modulus,elasticity imaging
    求助PDF
    上传PDF
    View via Publisher
    Bibtex
    AI Read Science
    AI Summary
    AI Summary is the key point extracted automatically understanding the full text of the paper, including the background, methods, results, conclusions, icons and other key content, so that you can get the outline of the paper at a glance.
    Example
    Background
    Key content
    Introduction
    Methods
    Results
    Related work
    Fund
    Key content
    • Pretraining has recently greatly promoted the development of natural language processing (NLP)
    • We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
    • We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
    • The model is scaled to large model with 10 billion parameters with sophisticated deployment, and the 10 -parameter M6-large is the largest pretrained model in Chinese
    • Experimental results show that our proposed M6 outperforms the baseline in a number of downstream tasks concerning both single modality and multiple modalities We will continue the pretraining of extremely large models by increasing data to explore the limit of its performance
    Upload PDF to Generate Summary
    Must-Reading Tree
    Example
    Generate MRT to find the research sequence of this paper
    Data Disclaimer
    The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn
    Chat Paper
    【要点】：研究提出剪切波弹性成像技术可用于检测急性肾损伤（AKI）患者的肾组织僵硬度的变化，发现AKI患者的肾刚度增加，并与肾损伤程度相关。
    

    【方法】：研究采用剪切波弹性成像（SWE）技术，通过评估肾的杨氏模量（YM）来衡量组织僵硬度的变化。
    

    【实验】：研究分为两部分，A部分通过对C57BL/6雄性小鼠进行盲肠结扎和穿刺（CLP）建立败血症相关AKI模型，并观察肾YM的变化；B部分包括54例连续重症患者，其中部分患者存在AKI，观察了患者肾YM的变化。数据集名称未在摘要中明确提及，但实验结果显示，CLP小鼠的肾YM显著高于假手术组，且随着时间逐渐增加，与肾小管损伤评分和血清肌酐有较好的相关性（R²=0.71和R²=0.73）。在患者中，AKI患者的肾YM较高，且随着AKI程度的加重逐渐升高，肾YM与肾损伤分子-1和中性粒细胞明胶酶相关脂钙素（NGAL和KIM-1）有一定的相关性（R²在0.4到0.58之间），但对于AKI的诊断效果并不优于NGAL和KIM-1。