Fbxo2CreERT2: A new model for targeting cells in the neonatal and mature inner ear

Melissa M. McGovern,Byron Hartman,Ankita Thawani,Helen Maunsell,Hongyuan Zhang,Rizwan Yousaf,Stefan Heller,Jennifer Stone,Andrew K. Groves

Hearing Research（2022）

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摘要

•Fbxo2CreERT2 provides a new tool for manipulating gene expression the inner ear.•Recombination occurs throughout the cochlear duct in the neonatal and adult inner ear.•Hair cells in the neonatal vestibular end organs are targeted by Fbxo2CreERT2.•Fbxo2CreERT2 recombination is enriched in Type 1 hair cells in the mature maculae and cristae of the vestibular system.

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关键词

CreER/LoxP,Cochlea,Vestibular,Utricle,Fbxo2,Fbx2

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