Tailored Treatment based on H. pylori Genetic Markers of Resistance is Associated with Higher Eradication Success.

Increasing antimicrobial resistance with Helicobacter pylori infection has focused efforts to tailor eradication therapy based on identifying genetic markers of resistance to predict antimicrobial susceptibility. In this retrospective study, we report the impact of routine inclusion of antimicrobial susceptibility testing and recommendations for eradication therapy with gastric specimens with H. pylori. The use of a recommended treatment regimen based on genetic markers of resistance was associated with an 84% rate of eradication success and 4.4 greater odds of eradication relative to unrecommended treatment. This is the first study describing use of H. pylori genetic resistance testing as standard of care.