MOTS-c and aerobic exercise induce cardiac physiological adaptation via NRG1/ErbB4/CEBPβ modification in rats

Jinghan Yuan,Bowen Xu,Jiacheng Ma,Xiaoli Pang,Yu Fu,Min Liang,Manda Wang,Yanrong Pan,Yimei Duan,Mi Tang, Bingmei Zhu,Ismail Laher,Shunchang Li

Life Sciences（2023）

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摘要

Our findings suggest that MOTS-c and aerobic exercise had similar effects, improving myocardial morphology and structure and enhancing cardiac function through activation of the NRG1-ErbB4-C/EBPβ pathway.

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关键词

MOTS-c,Aerobic exercise,Cardiac physiological adaptation,Neuregulin 1,ErbB4,C/EBPβ

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