Autoimmune atrophic gastritis and coeliac disease: A case-control study

Background: Autoimmune atrophic gastritis (AAG) is rarely associated with coeliac disease (CD). Aims: To assess the frequency of AAG-CD association and to compare clinical, biochemical, and histolog-ical features of adults affected by both diseases (cases) with AAG controls.Methods: This case-control study included 9 cases (F55%, median age 47, range 23-59yrs) matched (1:3) by age ( +/- 4 yrs) and gender to 27 controls randomly selected from our AAG cohort (2009-2021). The AAG and CD diagnosis was based on internationally agreed criteria.Results: Of 434 AAG patients (median age:62.5yrs, range18-92yrs, F:M ratio = 2.2:1),9 had a concomitant diagnosis of CD. The occurrence of AAG-CD association was 2% and 1.65% among AAG/CD cohorts, re-spectively. Cases were significantly younger than AAG cohort (n = 425, p = 0.002). In 4/9cases, AAG was diagnosed by proactive screening for autoimmune disorders. Autoimmune thyroid disorders were present in 5/9 cases. Cases had a significant higher prevalence of normocytic anaemia than controls (p = 0.004). No significant differences were found between cases and controls concerning clinical and histological fea-tures.Conclusions: AAG-CD association is rare. Gastric and duodenal biopsies might be advisable in young peo-ple with normocytic anaemia and associated autoimmune disorders to timely diagnose clinically silent conditions.(c) 2022 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.