Testing for EGFR Variants in Pleural and Pericardial Effusion Cell-Free DNA in Patients With Non-Small Cell Lung Cancer.

Kirsty W C Lee,Molly S C Li,Wanxia Gai,Yat Ming Lau,Allen K C Chan,Oscar S H Chan,Chee Khoon Lee,Rebecca M W Yeung,Sherwood Y H Fung,Wai F Cheung,Vivian W Chan,Linda Leung, Kenny N P Kam,Tony S K Mok

JAMA oncology（2023）

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摘要

In this diagnostic study, EGFR variants could be accurately detected from PE-cfDNA in patients with NSCLC. More EGFR T790M was detected in PE-cfDNA than in guideline-recommended PE cell block preparations. These results suggest that PE-cfDNA can complement plasma and tumor genotyping for detecting EGFR variants in patients with advanced NSCLC.

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