Optimized integration of metabolomics and lipidomics reveals brain region-specific changes of oxidative stress and neuroinflammation in type 1 diabetic mice with cognitive decline

•Over 4000 metabolite and 6000 lipid features were detected in the mouse brain using the optimized extraction method.•Lipid disorders are more significant in the frontal cortex than the hippocampus in T1D mice.•Neuroinflammation is more pronounced in the frontal cortex than the hippocampus in T1D mice.•Brain region-specific shifts in oxidant stress may cause diabetic cognitive decline.•The frontal cortex might be a major target brain region of oxidant stress in T1D mice.