PIEZO1 Channels in Cutaneous Free Nerve Endings: Novel Insights into Itch-Scratch-mechanisms

Manuel Pedro Pereira,Henning Wiegmann,Sonja Ständer

Signal transduction and targeted therapy（2023）

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摘要

A recent study published in Nature by Hill et al.1 identified mechano-sensitive PIEZO1 ion channels in pruriceptive neurons.Remarkably,PIEZO1 is involved in acute itch transmission and in mechanical alloknesis in chronic pruritus(CP)states.

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